abstract：:Although there are no proven ways to delay onset or slow progression of Alzheimer's disease (AD), studies suggest that diet can affect risk. Pomegranates contain very high levels of antioxidant polyphenolic substances as compared to other fruits and vegetables. Polyphenols have been shown to be neuroprotective in diff...

journal_title：Neurobiology of disease

authors： Hartman RE,Shah A,Fagan AM,Schwetye KE,Parsadanian M,Schulman RN,Finn MB,Holtzman DM

更新日期：2006-12-01 00:00:00

abstract：:Butyrylcholinesterase (BuChE) is increased in the cerebral cortex of Alzheimer's disease (AD) patients, particularly those carrying epsilon4 allele of the apolipoprotein E gene (ApoE) and certain BuChE variants that predict increased AD risk and poor response to anticholinesterase therapy. We measured BuChE activity a...

journal_title：Neurobiology of disease

authors： Darreh-Shori T,Brimijoin S,Kadir A,Almkvist O,Nordberg A

更新日期：2006-11-01 00:00:00

abstract：:Huntingtin, the protein product of the Huntington's disease (HD) gene, is known to interact with the tumor suppressor p53. It has recently been shown that activation of p53 upregulates the level of huntingtin, both in vitro and in vivo, whereas p53 deficiency in HD-transgenic flies and mice has been found to be benefi...

journal_title：Neurobiology of disease

authors： Ryan AB,Zeitlin SO,Scrable H

更新日期：2006-11-01 00:00:00

abstract：:Mutations in the DNA-binding domain of EGR2 are associated with severe autosomal dominant forms of peripheral neuropathy. In this study, we show that one such Egr2 mutant (S382R, D383Y), when expressed in Schwann cells in vitro, is not transcriptionally inactive but retains residual wild-type Egr2 functions, including...

journal_title：Neurobiology of disease

authors： Arthur-Farraj P,Mirsky R,Parkinson DB,Jessen KR

更新日期：2006-10-01 00:00:00

abstract：:Focal cortical dysplasia (FCD) and glioneuronal tumors (GNT) are recognized causes of chronic intractable epilepsy. The cellular mechanism(s) underlying their epileptogenicity remain largely unknown. Compelling evidence in experimental models of seizures indicates an important role of interleukin (IL)-1beta in the mec...

journal_title：Neurobiology of disease

authors： Ravizza T,Boer K,Redeker S,Spliet WG,van Rijen PC,Troost D,Vezzani A,Aronica E

更新日期：2006-10-01 00:00:00

abstract：:Dietary or pharmacological manipulation of plasma lipids markedly influences amyloid deposition in animal models of Alzheimer's Disease (AD). However, it is not known whether baseline plasma lipids in AD models differ from wild-type littermates throughout the natural history of disease. To address this question, we me...

journal_title：Neurobiology of disease

authors： Burgess BL,McIsaac SA,Naus KE,Chan JY,Tansley GH,Yang J,Miao F,Ross CJ,van Eck M,Hayden MR,van Nostrand W,St George-Hyslop P,Westaway D,Wellington CL

更新日期：2006-10-01 00:00:00

abstract：:Axonal damage, a core feature of neurological diseases, induces a retrograde reaction in neurons and surrounding glia. We determined transcriptional profiles of this reaction using Affymetrix oligonucleotide arrays. Gene expression was examined in spinal cord tissue prior to injury and following ventral root avulsion ...

journal_title：Neurobiology of disease

authors： Swanberg M,Duvefelt K,Diez M,Hillert J,Olsson T,Piehl F,Lidman O

更新日期：2006-10-01 00:00:00

abstract：:Neurodegeneration is a common neuropathological feature of prion diseases. Although evidence of apoptosis was found in natural and experimental prion diseases, the precise mechanisms by which neurons die are poorly understood. The pro-apoptotic BAX protein, a key factor of the mitochondrial pathway, plays a central ro...

journal_title：Neurobiology of disease

authors： Coulpier M,Messiaen S,Hamel R,Fernández de Marco M,Lilin T,Eloit M

更新日期：2006-09-01 00:00:00

abstract：:Immunization of mouse models of Alzheimer disease (AD) with amyloid-peptide (Abeta) reduces Abeta deposits and attenuates their memory and learning deficits. Recent clinical trials were halted due to meningoencephalitis, presumably induced by T cell mediated and/or Fc-mediated immune responses. Because injection of an...

journal_title：Neurobiology of disease

authors： Fukuchi K,Tahara K,Kim HD,Maxwell JA,Lewis TL,Accavitti-Loper MA,Kim H,Ponnazhagan S,Lalonde R

更新日期：2006-09-01 00:00:00

abstract：:Drugs that modify noradrenergic transmission such as atomoxetine and clonidine are increasingly prescribed for the treatment of attention deficit hyperactivity disorder (ADHD). However, the therapeutic targets of these compounds are unknown. Norepinephrine is also implicated in the hyperactivity exhibited by coloboma ...

journal_title：Neurobiology of disease

authors： Bruno KJ,Hess EJ

更新日期：2006-09-01 00:00:00

abstract：:Cytokine-dependent mechanisms in the CNS have been implicated in the pathogenesis of depression. Interleukin-6 is upregulated in depressed patients and dowregulated by antidepressants. It is, however, unknown whether IL-6 is involved in the pathogenesis of depression. We subjected IL-6-deficient mice (IL-6(-/-)) to de...

journal_title：Neurobiology of disease

authors： Chourbaji S,Urani A,Inta I,Sanchis-Segura C,Brandwein C,Zink M,Schwaninger M,Gass P

更新日期：2006-09-01 00:00:00

abstract：:Our previous studies demonstrated that the psychostimulant methamphetamine (MA) and the human immunodeficiency virus-1 (HIV-1) protein Tat interacted to cause enhanced dopaminergic neurotoxicity. The present study examined whether tumor necrosis factor-alpha (TNF-alpha) mediates the interaction between Tat and MA. In ...

journal_title：Neurobiology of disease

authors： Theodore S,Cass WA,Nath A,Steiner J,Young K,Maragos WF

更新日期：2006-09-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal disease of unknown etiology. Mutations in copper/zinc superoxide dismutase (SOD1) are the most commonly associated genetic abnormality. Given that SOD1 is ubiquitously expressed, the exclusive vulnerability of motor neurons is one of the most puzzling issues in ALS resear...

journal_title：Neurobiology of disease

authors： Ge WW,Leystra-Lantz C,Sanelli TR,McLean J,Wen W,Strong W,Strong MJ

更新日期：2006-08-01 00:00:00

abstract：:The role of endothelial nitric oxide (NO) in the cerebrovascular response to partial seizures was investigated in mice deleted for the endothelial NO synthase gene (eNOS-/-) and in their paired wild-type (WT) congeners. Local cerebral blood flow (LCBF, quantitative [14C]iodoantipyrine method) was measured 3-6 h after ...

journal_title：Neurobiology of disease

authors： Pereira de Vasconcelos A,Riban V,Wasterlain C,Nehlig A

更新日期：2006-07-01 00:00:00

abstract：:The hyh mouse carrying a point mutation in the gene encoding for soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein alpha (alpha-SNAP) develops inherited hydrocephalus. The investigation was designed to study: (i) the clinical evolution of hyh mice; (ii) factors other than the alpha-SNAP mutation that ...

journal_title：Neurobiology of disease

authors： Bátiz LF,Páez P,Jiménez AJ,Rodríguez S,Wagner C,Pérez-Fígares JM,Rodríguez EM

更新日期：2006-07-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection continues to rise in drug-abusing populations and causes a dementing illness in a subset of individuals. Factors contributing to the development of dementia in this population remain unknown. We found that HIV-infected individuals with the E4 allele of Apolipoprotein E (Apo...

journal_title：Neurobiology of disease

authors： Turchan-Cholewo J,Liu Y,Gartner S,Reid R,Jie C,Peng X,Chen KC,Chauhan A,Haughey N,Cutler R,Mattson MP,Pardo C,Conant K,Sacktor N,McArthur JC,Hauser KF,Gairola C,Nath A

更新日期：2006-07-01 00:00:00

abstract：:Since electrophysiological correlates of L-dopa-induced dyskinesia (LID) are almost unknown, changes of striatal dopamine (DA) transmission and electrophysiological activity of the substantia nigra pars reticulata (SNr) were recorded before and after acute L-dopa administration in sham-operated and 6-hydroxydopamine (...

journal_title：Neurobiology of disease

authors： Meissner W,Ravenscroft P,Reese R,Harnack D,Morgenstern R,Kupsch A,Klitgaard H,Bioulac B,Gross CE,Bezard E,Boraud T

更新日期：2006-06-01 00:00:00

abstract：:Alpha-synuclein containing cellular inclusions are a hallmark of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. A genome wide expression screen was performed in C. elegans overexpressing both wild-type and A53T human alpha-synuclein. 433 genes were up- and 67 genes down-regulated by statistical an...

journal_title：Neurobiology of disease

authors： Vartiainen S,Pehkonen P,Lakso M,Nass R,Wong G

更新日期：2006-06-01 00:00:00

abstract：:To decipher the pathway of apoptosis induction downstream to caspase-8 activation by exogenous expression of Hippi, an interactor of huntingtin-interacting protein Hip1, we studied apoptosis in HeLa and Neuro2A cells expressing GFP-tagged Hippi. Nuclear fragmentation, caspase-1, caspase-8, caspase-9/caspase-6 and casp...

journal_title：Neurobiology of disease

authors： Majumder P,Chattopadhyay B,Mazumder A,Das P,Bhattacharyya NP

更新日期：2006-05-01 00:00:00

abstract：:There is clear evidence that an inflammatory reaction is mounted within the CNS following trauma, stroke, infection and seizures, thus augmenting brain damage. Furthermore, chronic inflammation of the CNS is implicated in many neurodegenerative disorders. However, the effects of products of inflammation on neuronal ce...

journal_title：Neurobiology of disease

authors： Ogburn KD,Bottiglieri T,Wang Z,Figueiredo-Pereira ME

更新日期：2006-05-01 00:00:00

abstract：:Amyloid beta-peptide (Abeta) containing plaques and neurofibrillary tangles (NFT) are the two major histopathological hallmarks of Alzheimer's disease (AD). According to the amyloid cascade hypothesis, deposition of Abeta is an initial and essential step in the pathogenesis of AD, and formation of NFT has been propose...

journal_title：Neurobiology of disease

authors： Kulic L,Kurosinski P,Chen F,Tracy J,Mohajeri MH,Li H,Nitsch RM,Götz J

更新日期：2006-04-01 00:00:00

abstract：:Photoreceptor cell death is an irreversible, pathologic event in many blinding retinal diseases including retinitis pigmentosa, age-related macular disease, and retinal detachment. Light exposure can exacerbate a variety of human retinal diseases by increasing the rate of photoreceptor cell death. In the present study...

journal_title：Neurobiology of disease

authors： Kong L,Li F,Soleman CE,Li S,Elias RV,Zhou X,Lewis DA,McGinnis JF,Cao W

更新日期：2006-03-01 00:00:00

abstract：:Genetic and biochemical abnormalities associated with alpha-synuclein are implicated in the etiology of Parkinson's disease (PD). In this study, altered locomotor behavior linked to the expression of mutant or wildtype human alpha-synuclein was investigated. A53T alpha-synuclein transgenic (A53T-tg) mice exhibited nor...

journal_title：Neurobiology of disease

authors： Unger EL,Eve DJ,Perez XA,Reichenbach DK,Xu Y,Lee MK,Andrews AM

更新日期：2006-02-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized behaviorally by chorea, incoordination, and shortened lifespan and neuropathologically by huntingtin inclusions and neuronal degeneration. In order to facilitate studies of pathogenesis and therapeutics, we have generated a new...

journal_title：Neurobiology of disease

authors： Tanaka Y,Igarashi S,Nakamura M,Gafni J,Torcassi C,Schilling G,Crippen D,Wood JD,Sawa A,Jenkins NA,Copeland NG,Borchelt DR,Ross CA,Ellerby LM

更新日期：2006-02-01 00:00:00

abstract：:Precursor cells in the adult dentate gyrus are a heterogeneous population. Astrocytic cell types with radial glia-like morphology and low proliferative activity have been distinguished from highly dividing subtypes expressing early neuronal properties. Recent evidence indicates that physiological stimuli predominantly...

journal_title：Neurobiology of disease

authors： Kunze A,Grass S,Witte OW,Yamaguchi M,Kempermann G,Redecker C

更新日期：2006-02-01 00:00:00

abstract：:Systemic delivery of recombinant Bcl-xL fusion protein containing the TAT protein transduction domain attenuated neonatal brain damage following hypoxic ischemia (H-I). Within 30 min after intraperitoneal injection of TAT-Bcl-xL protein into 7-day-old rats, substantially enhanced levels of Bcl-xL were found in several...

journal_title：Neurobiology of disease

authors： Yin W,Cao G,Johnnides MJ,Signore AP,Luo Y,Hickey RW,Chen J

更新日期：2006-02-01 00:00:00

abstract：:Approximately 10% of amyotrophic lateral sclerosis (ALS) cases are familial (FALS), and approximately 25% of FALS cases are caused by mutations in superoxide dismutase-1 (SOD1). Mutant (MT) SOD1 kills motor neurons because of the mutant protein's toxicity; however, the basis for toxicity is unknown. We electroporated ...

journal_title：Neurobiology of disease

authors： Ghadge GD,Wang L,Sharma K,Monti AL,Bindokas V,Stevens FJ,Roos RP

更新日期：2006-01-01 00:00:00

abstract：:The aim of the present study is to better understand oxygen-sensitive adaptative pathways underlying the hypoxic preconditioning-induced protection of the brain against ischemia. Using oligonucleotide microarrays, we examined the brain genomic response of adult mice following hypoxia preconditioning (8% O2 for 1 or 6 ...

journal_title：Neurobiology of disease

authors： Tang Y,Pacary E,Fréret T,Divoux D,Petit E,Schumann-Bard P,Bernaudin M

更新日期：2006-01-01 00:00:00

abstract：:Endocannabinoids function as neurotransmitters and neuromodulators in the central nervous system via specific receptors and apparently have a neuroprotective role. We assumed that the endocannabinoid system could be involved in the pathogenesis of hepatic encephalopathy (HE), a neuropsychiatric syndrome due to liver d...

journal_title：Neurobiology of disease

authors： Avraham Y,Israeli E,Gabbay E,Okun A,Zolotarev O,Silberman I,Ganzburg V,Dagon Y,Magen I,Vorobia L,Pappo O,Mechoulam R,Ilan Y,Berry EM

更新日期：2006-01-01 00:00:00

abstract：:Familial amyotrophic lateral sclerosis (FALS) has been modeled in transgenic mice by introducing mutated versions of human genomic DNA encompassing the entire gene for Cu,Zn superoxide dismutase (SOD1). In this setting, the transgene is expressed throughout the body and results in mice that faithfully recapitulate man...

journal_title：Neurobiology of disease

authors： Wang J,Xu G,Slunt HH,Gonzales V,Coonfield M,Fromholt D,Copeland NG,Jenkins NA,Borchelt DR

更新日期：2005-12-01 00:00:00

abstract：:Chronic inflammation is known to play an important role in the heterogeneous pathogenesis of Alzheimer's disease (AD). Activated astrocytes expressing glial fibrillary acidic protein (GFAP) are closely associated with AD pathology, such as tangles, neuritic plaques and amyloid depositions. Altogether, 46 soluble isofo...

journal_title：Neurobiology of disease

authors： Korolainen MA,Auriola S,Nyman TA,Alafuzoff I,Pirttilä T

更新日期：2005-12-01 00:00:00

abstract：:Exposure to stress during pregnancy influences the trajectory of brain development resulting in permanent alterations that may contribute to increased susceptibility to subsequent cognitive or neuropsychiatric disorders. In this manuscript, we examined the effects of prenatal stress on the expression of basic fibrobla...

journal_title：Neurobiology of disease

authors： Fumagalli F,Bedogni F,Slotkin TA,Racagni G,Riva MA

更新日期：2005-12-01 00:00:00

abstract：:It is well established that the conversion of PrP(C) to PrP(Sc) is the key event in prion disease biology. In addition, several lines of evidence suggest that glycosaminoglycans (GAGs) and in particular heparan sulfate (HS) may play a role in the PrP(C) to PrP(Sc) conversion process. It has been proposed that PrP(Sc) ...

journal_title：Neurobiology of disease

authors： Mayer-Sonnenfeld T,Zeigler M,Halimi M,Dayan Y,Herzog C,Lasmezas CI,Gabizon R

更新日期：2005-12-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra and a marked reduction of dopamine (DA) levels in the striatum. Binding to its specific receptors, DA switches on a complex program of intracellular signaling that regulates gene ex...

journal_title：Neurobiology of disease

authors： Cuadrado-Tejedor M,Sesma MT,Giménez-Amaya JM,Ortiz L

更新日期：2005-12-01 00:00:00

abstract：:We have shown that over-expression of human tau (0N3R) in Drosophila larval motor neurons causes significant morphological and functional disruption to the neuromuscular junctions (NMJs). Tau-expressing NMJs are reduced in size with irregular and abnormal bouton structure. Immunocytochemical analysis shows that the ab...

journal_title：Neurobiology of disease

authors： Chee FC,Mudher A,Cuttle MF,Newman TA,MacKay D,Lovestone S,Shepherd D

更新日期：2005-12-01 00:00:00

abstract：:In multiple sclerosis (MS), post-mortem studies of human brain tissue as well as data from animal models have shown that apoptosis of neurons occurs to a significant extent during this disease. As neurodegeneration in MS correlates with permanent neurological deficits in patients, understanding the mechanisms would be...

journal_title：Neurobiology of disease

authors： Diem R,Taheri N,Dietz GP,Kuhnert A,Maier K,Sättler MB,Gadjanski I,Merkler D,Bähr M

更新日期：2005-11-01 00:00:00

abstract：:We used quantal dose-titration of a mouse-adapted human transmissible spongiform encephalopathy strain (M470) to compare different analytical methods for their ability to detect asymptomatic brain prion infection after low dose inoculation. At a time point approximately 2.5-fold beyond the mean incubation period of hi...

journal_title：Neurobiology of disease

authors： Collins SJ,Lewis V,Brazier MW,Hill AF,Lawson VA,Klug GM,Masters CL

更新日期：2005-11-01 00:00:00

abstract：:Taking advantage of a progressive nonhuman primate model mimicking Parkinson's disease (PD) evolution, we monitored transcriptional fluctuations in the substantia nigra using Affymetrix microarrays in control (normal), saline-treated (normal), 6 days-treated (asymptomatic with 20% cell loss), 12 days-treated (asymptom...

journal_title：Neurobiology of disease

authors： Bassilana F,Mace N,Li Q,Stutzmann JM,Gross CE,Pradier L,Benavides J,Ménager J,Bezard E

更新日期：2005-10-01 00:00:00

abstract：:To thoroughly understand the function and regulation of neurotransmitter systems in the brain, as well as the underlying disease mechanisms, it is important to comprehensively analyze the expression patterns of genes participating in such systems. Using functional annotated cDNA clones (FANTOM), we examined the gene e...

journal_title：Neurobiology of disease

authors： Ichikawa M,Okamura-Oho Y,Okunishi R,Kanamori M,Suzuki H,Ritani A,Nitta H,Eguchi N,Urade Y,Hayashizaki Y

更新日期：2005-08-01 00:00:00

abstract：:Although the incidence of seizures after a cerebrovascular event including intracerebral hemorrhage has been widely recognized, the present studies have demonstrated that generalized convulsive seizures can cause multifocal amygdaloallocortical hemorrhage and tissue necrosis, the origin of which remains to be establis...

journal_title：Neurobiology of disease

authors： Mraovitch S,Calando Y,Régnier A,Lamproglou I,Vicaut E

更新日期：2005-08-01 00:00:00